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Retatrutide's 24.2% at 48 weeks in a smaller phase 2 trial suggests a numerically greater weight loss signal, attributed in part to the added GCGR-mediated energy expenditure increase, but no head-to-head RCT exists

In a 26-week phase 2 study in type 2 diabetes, orforglipron reduced HbA1c by as much as roughly 2.1 percentage points (about 1.7 points placebo-adjusted), versus about 0.4 points with placebo and 1.1 points with the injectable peptide comparator dulaglutide

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Studies consistently find dieting and exercising are, in practice, ineffective solutions for weight management

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Most people notice appetite reduction within 12 weeks and measurable weight loss within 46 weeks, with steady progress over 36 months of consistent therapy