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Given various advantages, such as easy tissue penetration, low toxicity, and low immunogenicity, exosomes are believed to be a reliable drug delivery system able to selectively target specific cells (Figure 1)

This makes it useful for studying mechanisms involved in satiety, food intake, and downstream metabolic effects in both preclinical models and clinical research settings

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The weight loss effect depends specifically on AMY1R and AMY3R activation, as confirmed by a study in eBioMedicine that showed cagrilintide lowers body weight through these specific receptor subtypes in the brainstem