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Andreeff M , Konopleva M, Carter B, Zhang W, Samudio I, Ruvolo P, Reed JC, Garzon R, Croce C, Champlin R, Andersson B, de Lima M, Murphy W, Plunkett W, Cortes J, Borthkaur G, Estey E, O'Brien S, Kornblau S, Berry D, Kantarjian H

Recent research has showed that GDF15 regulate SLC7A11 expression, and GDF15 knockdown promote erastin-induced ferroptosis by repressing SLC7A11 expression and suppressing the function of System X c ( Another therapeutic target that regulates GC ferroptosis, SLC7A11, its inhibitor Erastin hampers the survival of GC (Sun et al., 2020)

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Thus, antioxidants are crucial for neutralizing the overproduction of ROS