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Results showed a biphasic plasma concentrationtime profile, with an initial peak occurring within 24 h (initial absorption rate of 0.02 L/h) and a secondary sustained release phase (delayed absorption rate of 0.01 L/h) attributed to the gradual degradation of PLGA

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Weight change typically reflects an individual's energy balance, daily movement, sleep patterns, appetite, stress levels, and adherence to a diet over time