The mammalian lipoxygenase family includes six distinct isoforms (ALOXE3, ALOX5, ALOX12, ALOX12B, ALOX15, and ALOX15B), and the researchers found that only the absence of ALOX12 significantly reduced ferroptosis
Ashby J, Basketter DA, Paton D, & Kimber I (1995) Structure activity relationships in skin sensitizing sensitization using the murine local lymph node assay
Glutathione is an essential cofactor for enzymes involved in liver detoxification reactions (especially Phase II)
Clinical and laboratory assessments All Patients were subjected to the following: History taking includes demographic data (age, gender, and residence) and time elapsed post-envenomation till reached APC
Glutathione helps maintain the body's natural antioxidant balance by participating in systems that neutralise oxidative stress at the cellular level
Early Response Indicators: Early reductions in fasting serum glucose [8] and body weight with tirzepatide were associated with better long-term metabolic outcomes, suggesting that early response may inform treatment individualization
