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did not find any significant changes of renin, aldosterone, and urinary angiotensinogen after a single GLP-1 infusion in healthy men 28 and the same result was reported in patients with diabetes without kidney function impairment 32

Higher Discontinuation Rates: The triplet therapy group had a 28.3% discontinuation rate due to tolerability issues and adverse events, significantly higher than the 4% to 10% seen in the semaglutide-only or semaglutide + trevogrumab groups

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Stigma against patients and crisis fatigue are the only reasons that deaths from addiction are not treated with the same urgency as deaths from novel infections

Beyond vanity drugs To persuade payers that next-gen obesity therapies are more than vanity drugs, pharma companies must continue to study them in a range of clinical trials