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This is essential to clarify whether metabolite-associated effects account for many of the health-related outcomes attributed to HTY intake

SEAMARK: Randomized phase 2 study of pembrolizumab + encorafenib + cetuximab vs pembrolizumab alone for first-line treatment of BRAF V600Emutant microsatellite instabilityhigh (MSI-H)/mismatch repair deficient (dMMR) metastatic colorectal cancer (CRC)

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A study referenced by the National Institutes of Health (NIH) noted that vitamin B12 deficiency is associated with higher body weight and fat mass, suggesting that ongoing supplementation can provide metabolic benefits even beyond the initial weight loss phase

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