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Truncation This is the most fundamental distinction between the two analogs: IGF-1 LR3 is a longer molecule than native IGF-1 it adds 13 amino acids to the N-terminus plus makes the R3 point substitution, creating an 83-aa peptide

TAL also releases several cytokines, such as IL10 and TGF, contributing to the immunosuppressive environment

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Furthermore, imaging-guided personalization facilitates adaptive therapy, where hydrogel placement and composition can be modified over the course of treatment to account for tumor response, evolving hypoxia, or treatment-induced anatomical changes

Taber et al., 2006)