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Neurexins-SS4+, a splicing variant containing exon 20 on the SS4 fragment, exhibits only weak adhesion and binding properties, and when exon 20 of SS4 is spliced, synapses exhibit strong adhesion and mutual binding [75, 76]
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This decline is accelerated by external factors like UV exposure and internal factors like stress
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J Pediatr Surg 1983
The study enrolled 1,961 participants with a BMI of 30 kg/m 2 or greater (or 27 kg/m 2 in persons with one or more weight-related coexisting conditions) who did not have diabetes and were randomly assigned to once-weekly 2.4 mg subcutaneous semaglutide or placebo plus lifestyle intervention for 68 weeks
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