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We generated fully human antibodies to specifically block GDF8 (trevogrumab) and ActA (garetosmab), and showed that combining these blocking antibodies results in much greater increases in muscle than either of the antibodies individually, with dual blockade matching the muscle growth induced by broader ActRIIA/B pathway blockade in both mice and non-human primates (NHPs) 28,31

Additionally, around 12% of oxygen used in mitochondrial metabolism produces free radicals, which can lead to oxidative stress and even DNA damage [2]

10.1016/j.bbr.2020.113040 53 GuilfordB

10.1002/hipo.10220 52 ClaassenJ

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