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Combining both modalities reflects a precision medicine approachtreating insulin resistance, appetite dysregulation, and hormonal imbalance rather than weight loss as a single isolated problem

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The STEP 2 trial, which included individuals with type 2 diabetes, reported an average weight loss of approximately 9.6%

Peer review Peer review information Nature Reviews Endocrinology thanks Juan Pablo Frias, Baptist Gallwitz and the other, anonymous, reviewer(s) for their contribution to the peer review of this work