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Comprehensive reviews demonstrate that dietary patterns influence mitochondrial membrane composition, electron transport efficiency, and susceptibility to oxidative injury, reinforcing nutrition as a primary determinant of mitochondrial redox tone rather than a passive modifier (25-26)
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AGE/RAGE action on vascular smooth muscle cells (VSMC) induces autophagy through the ERK/Akt pathway 454 and increases ROS and NOS levels through activation of NOX and NF-B, 455,456 increases oxidative stress, and accelerates atherosclerotic plaque progression
Glutathione works as a powerful antioxidant by neutralizing free radicals and protecting cells from oxidative damage
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Acetyl-carnitine typically increases during -oxidation, a process of energy production from fatty acids [23]
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