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The results indicated that LMP mutation carriers had a 3.03% lower overall weight loss compared to non-carriers, with no significant difference in short-term outcomes ( 6 months) but a significant reduction in long-term outcomes

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Starting at a lower dose and gradually titrating upwards, as recommended in the prescribing information, can help minimise these effects

Managing Side Effects During Dose Increases Nausea and appetite loss are expected during the first few days after a dose increase, typically resolving within 5 to 7 days as your body adjusts

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