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Recent reviews were used selectively for conceptual background, theoretical framing, and cross-referencing of relevant primary literature

Statistical analyses were performed using GraphPad Prism 8 software (GraphPad Software, USA)

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Altintas stressed that The findings should be viewed as hypothesis-generating rather than practice-changing. The study suggests that semaglutide does not appear to increase fracture risk and may potentially reduce it, but randomized prospective studies with bone mineral density, bone turnover markers, and fracture endpoints will be needed before concluding that semaglutide has true bone-protective properties, he told us

In addition, GLP-1 inhibits glucagon secretion in islet alpha cells, but only when blood glucose levels are higher than fasting (95, 96)