Hypothyroidism Hypothyroidism is associated with several derangements in kidney function, including decreased renal blood flow, filtration, and sodium reabsorption, and may be associated with progression of CKD (Kim, Lee 2014)
Heme oxygenase 1 (HO-1) is a protective enzyme with antioxidant, anti-inflammatory and anti-apoptotic effects, which has been intensively studied and plays an important role in diabetic complications
When combined with chronic low grade inflammation, this proinflammatory pleiotropic cytokine might switch from self recognition to loss of self-recognition or autoimmune status (De Benedetti et al., 2021)
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