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Jim Eggeman, a 911 operator in Ohio, said that before taking semaglutide, I could sit down and eat a large pizza, and now its one to two pieces at the most. He started on the drug for diabetes after a heart attack in December 2019 and lost 35 pounds, bringing his weight to 220

FDA Clears First Oral GLP-1 for Weight Loss On December 22, 2025, the FDA approved Novo Nordisks once-daily Wegovy pill (25 mg semaglutide), the first oral GLP-1 receptor agonist indicated for chronic weight management and cardiovascular risk reduction in adults with obesity or overweight plus at least one weight-related comorbidity