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The data in Figure 6 represent the results of vitamin B-12deficient patients who were mistakenly prescribed daily doses of folic acid (0.41.0 mg) for 12 to 67 d before measurement of tHcy and MMA, followed by subsequent correction by vitamin B-12 administration
also showed no significant increases in GFR in uncontrolled studies on rhGH-treatment in children with CKD stages 34 (median GFR, 19 ml/min/1.73 m 2 ) and after KTx (median GFR, 47 ml/min/1.73 m 2 ) after a 6-week treatment period [168]
doi: 10.1016/0141-3910(82)90029-5
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Elevated serum B12 levels often indicate underlying conditions such as haematological disorders, liver disease, or renal impairment rather than toxicity from supplementation