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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

A few commenters called for increased transparency around the methodology including clearer documentation on how hospitals are grouped into peer comparisons, how quartiles are calculated, and how measure groups contribute to the Overall Hospital Quality Star Rating, to help hospitals anticipate and manage performance

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Most of the structural changes during the conformational switch in gB happen between domains, leaving the individual domains as rigid bodies (Supplementary Discussion and Supplementary Figs