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We also assess the potential mechanisms that contribute to the reduction in major adverse cardiovascular events in individuals treated with GLP1R agonists and highlight the emerging cardiovascular biology of novel GLP1-based multi-agonists currently in development

If side effects become problematic, lowering the dose before attempting further increases can help

If you have doubts, raise them before the clinician issues the Rx

However, the included trials were conducted on relatively small sample sizes, which may limit the ability to detect rare psychiatric outcomes

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