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Thus, NRF2 supports nucleotide biosynthesis through direct transcriptional mechanisms and by rewiring cellular metabolism to funnel metabolic intermediates into the pathways

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These findings support the concept that the microbiota indirectly modulates -cell subpopulations through the adipose tissueinflammationinsulin resistance and SCFA/LPSincretins-cells axes, even though direct single-cell studies demonstrating differential responses of individual -cell subtypes to microbiota-derived metabolites are not yet available (Doumatey et al., 2020)

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