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The combination yields greater weight loss than either agent alone, with mean reductions in body weight of approximately 20.4% over 68 weeks in non-diabetic adults and 13.7% in those with type 2 diabetesfar exceeding placebo and monotherapy arms

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Moreover, the actions of SGLT2i are associated with increased insulin sensitivity and decreased albuminuria (Jaikumkao et al., 2018)

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