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Wong M et al

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ANALYSIS OF THE PATENT LANDSCAPE FOR SEMAGLUTIDE AND TIRZEPATIDE This section examines the patent thicket that Novo Nordisk and Eli Lilly have built around the drugs Ozempic, Rybelsus and Wegovy (semaglutide) and Mounjaro and Zepbound (tirzepatide)

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Lassailly G, Caiazzo R, Buob D, et al

Semaglutide can attenuate inflammation in MASLD by downregulating the IRE1-XBP1-C/EBP (inositol-requiring transmembrane kinase/endonuclease-1-X-box binding protein 1-CCAAT/enhancer binding protein ) pathway in macrophages ( 2 ( 4.1.2 GLP-1RAs regulate the immune cells to protect the liver against fibrosis and neoplasia Exenatide and liraglutide can elevate cAMP levels and reduce the M1/M2 ratio through the cAMP-PKA-STAT3 pathway, resulting in amelioration of injured liver function and liver inflammation (Li et al., 2022