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Retatrutide (GLP-1/GIP/glucagon) reached ~24% TBWL at 48 weeks, with dramatic liver fat reduction
Leone-Bay A, Grant M, Greene S, Stowell G, Daniels S, Smithson A, et al
In addition, ALRN-6924, as the only stapled peptide drug that has entered clinical trials so far, has a serious drawback of not being able to produce long-term inhibition of related PPI in vivo
2013;305:L1002-1010
Data from a large retrospective US clinical care cohort study of 1,772,900 people with CKD (either low estimated glomerular filtration rate [eGFR] or abnormal albuminuria) representative of the general population was able to provide rates of hyperkalemia per 100 person years for different levels of eGFR and albuminuria, as well as by certain comorbidities (Supplementary Table 1) [21]
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