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For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

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Therefore, decreasing intracellular levels of GSH are associated with many diseases, such as age-related disorders and chronic diseases caused by oxidative stress [3]

Whether DSIP can meaningfully address the underlying dysregulation in narcolepsy is a question the PCAC review will likely examine

Therefore, our -EC production process using immobilized NsPCS can be performed at much lower cost and higher productivity rates with higher volumetric efficiency than current chemical production

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