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doi: 10.1530/joe-14-0638 18 YanWKangYJiXLiSLiYZhangGet al

This timeline aligns with typical semaglutide dose escalation and allows enough time for metabolic changes to influence thyroid hormone requirements

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The most commonly reported issues include nausea (especially during dose increases), gastrointestinal disturbances , reduced sleep quality, elevated resting heart rate (one user noted a 10 bpm increase by week 4), and acid reflux when eating late in the day

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Direct evidence for the exact combination is inadequate