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The other explanation might be that mitochondrial biogenesis per se is not always assayed

Always in mice, long-term light-dark shifts compromised intestinal integrity and amplified alcohol-induced endotoxemia and hepatic inflammation, highlighting the involvement of the gut-liver-immune axis in circadian disruption 129

Short Answer: DSIP has limited human evidence suggesting possible short-term improvements in sleep quality and sleep latency, but the research is small, outdated, and insufficient to establish it as a proven insomnia treatment

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Clin Transl Gastroenterol