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The glucagon receptor arm the addition that distinguishes retatrutide from dual GLP-1/GIP agonists activates energy expenditure pathways and accelerates hepatic lipid metabolism via cAMP/PKA (cyclic adenosine monophosphate/protein kinase A) signaling
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Am J Physiol Regul Integr Comp Physiol 305(7):R804R810 Poonam D, Vinay CS, Gautam P (2005) Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing