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Excessive testosterone production in PCOS is mainly due to the increased release of luteinizing hormone by the pituitary gland and the effects of a hyperinsulinemic state on the ovaries

In all sets of islets, tirzepatide consistently increased glucagon secretion, although the magnitude of glucagon secretion varied amongst donors (Fig

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These findings collectively suggest that the increased threonine catabolism to propionyl-CoA does not lead to an overall increase in propionyl-CoA levels, primarily due to a substantial decrease in the contribution from microbiome-derived propionate and the increase of propionyl-CoA flux to glucose synthesis