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Treated APP/PS1 mice showed significant improvements in spatial learning and memory compared to untreated transgenic controls, with molecular analysis confirming activation of PI3K/AKT signaling in hippocampal tissue

Annals of the New York Academy of Sciences, 1194 , 179189

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34, 35, 36 Further complementing this hypothesis are the observations that hepatic and intestinal permeability markedly increases for transcellular (and paracellular) tracers such as horseradish peroxidase and lanthanum in animals subjected to experimental colitis

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