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Hypocaloric diets, when not adjusted for protein density, increase the risk of disproportionate lean mass loss [41]

Those who continued the medication maintained or continued to lose weight, while those who stopped regained much of the weight lost, underscoring the need for long-term therapy.23 Longer-term outcomes were assessed in STEP 5, which extended treatment to 104 weeks and demonstrated sustained weight loss of approximately 15%.24 In East Asian populations, STEP 6 showed similar results, with participants achieving an average 12% to 13% weight loss over 68 weeks.25 STEP 7, a 44-week trial including participants from China, Hong Kong, Brazil, and South Korea, found that those on semaglutide lost an average of 12.1% of their body weight compared with 3.6% with placebo.26 Lastly, STEP 8 compared semaglutide with liraglutide and showed greater efficacy with semaglutide (15.8% vs 6.4% weight loss), as well as better tolerability and more convenient weekly dosing.27 Taken together, the STEP trials show that semaglutide consistently results in clinically meaningful weight loss across various populations and treatment conditions

Reducing or inhibiting FAO can turn off the energy source of cancer cells and starve them to death ( The majority of FAO happens in mitochondrion

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

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Furthermore, GLP1-RA is known to be associated with decreased all-cause mortality and cardiovascular mortality in the general diabetes population 19,20,21 , but real-world data in patients with moderate to advanced kidney disease is limited