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Methionine deactivates estrogen, which increase bile cholesterol

Conclusions To summarize, more than 19 years after exenatide's approval, newer once-weekly GLP-1 medicines like semaglutide and tirzepatide have shown long-term efficacy and safety for type 2 diabetes and obesity

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Short-acting peptides may clear within a day, while longer-acting peptides like semaglutide or tirzepatide can remain in the body for several weeks after the last dose

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10.1038/ki.2012.240 89 KimuraT.TakabatakeY.TakahashiA.KaimoriJ.MatsuiI.NambaT.et al (2011)