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Injected peptides reach systemic circulation fast and are employed when a direct, dependable effect is required

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Topical applications may show initial improvements in skin texture and hydration within 2-4 weeks, with more significant changes in collagen production and skin firmness becoming apparent after 8-12 weeks of consistent use

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Despite yielding the most reliable values and being less traumatic, micropuncture is limited by its depth of penetration which does not exceed 1 mm [11]

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