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Although the drugs can effectively reduce weight and improve some metabolic indicators, they are often accompanied by a decrease in fat-free mass, and this contradiction mainly arises from the inherent differences in research models, physiological backgrounds, and intervention conditions

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SURMOUNT-5 , the first direct comparison against semaglutide for weight loss, showed about 20.2% weight reduction with the dual-hormone drug versus about 13.7% with semaglutide over 72 weeks