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Its involvement in sleep-associated hormonal rhythms makes DSIP particularly relevant for studying the relationship between circadian biology and endocrine signaling

212,213,214 These DAMPs trigger gliotic responses, initially represented by migration of microglia and OPCs as described previously, and second, after the end of infarct expansion, reactive astrogliosis

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Oxidative stress is an imbalance between free radicals (unstable molecules that can damage cells) and antioxidants (molecules that neutralize them)