Tesofensine, conversely, works in the brain as a triple monoamine reuptake inhibitor, affecting serotonin, norepinephrine, and dopamine to suppress appetite
fMRI study of problem-solving after severe traumatic brain injury
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The gap between effective dose and optimal dose comes down to three variables most protocols overlook entirely: hepatocyte first-pass metabolism rates, blood-brain barrier saturation kinetics, and whether the study population has pre-existing synaptic deficits or intact baseline connectivity