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Split Dosing Option Some protocols call for splitting the daily dose into two administrations, typically morning and evening

It can bind to proteins in the blood, which allows it to provide a gentle, extended signal to the pituitary over several days

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Buyers with kidney disease should also consult a healthcare provider, since the kidneys are the primary site where L-Citrulline is converted to L-Arginine, and impaired renal function can affect amino acid processing in ways that aren't fully predictable from published research