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Horiguchi M, Arita M, Kaempf-Rotzoll DE, Tsujimoto M, Inoue K, Arai H

Hepatic fibrosis Hepatic fibrosis denotes the pathological accumulation of extracellular matrix (ECM) proteins following liver injury, a reparative response gone awry [43]

According to reports, the stimulation and maintenance of the myofibroblast phenotype are dependent on the transforming growth factor- (TGF-)/Smad, wingless/Integrated (Wnt), and yes-associated protein 1 (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) signaling pathways (Figure 1) (Piersma et al., 2015

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