Genetic, environmental, and psychological factors are implicated in its causation
History was taken and Disease activity had measured by (DAS28-ESR) Disease activity score 28 ESR from each patient and Ten, milliliters of blood were withdrawing from each control and patient, used for measurements of the GR Result : In studying of Glutathione reductase (GR) enzyme there are high enzyme concentration in human serum patient with Rheumatoid arthritis than the healthy control subject serum ( =10.622 5.213, =6.522 1.867 ng/ml) respectively with highly statically significant (T-Value 6.58, P- Value 5.1 that mean is patient with high disease activity [30-33]
Interestingly, despite the presence of superoxide dismutase (SOD) ( k = 2.4 10 9 M 1 s 1 ) 36 , the resulting concentration of H 2 O 2 is significantly smaller than the concentration of superoxide, indicating that the model is able to respond well to a transient increase in ROS, maintaining low H 2 O 2 concentrations
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Some studies have also used doses up to 4,500 mg per day
Sunlight damages collagen fibers (the major protein that gives structure to skin), elastin (a protein that maintains elasticity and strength of tissue beneath the skin), and it can also damage the critical vascular bed (fine capillaries) that provide oxygen & nutrients to skin tissue and remove waste