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This is why many physicians view tirzepatide as a long-term or indefinite treatment rather than a short course

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doi: 10.3390/nu14142869 47 FerrariSMFallahiPDi BariFVitaRBenvengaSAntonelliA

Both plasma GLP-2 and ileal Gcg mRNA levels were restored upon 2 days of refeeding or 4 days of continuous intragastric, but not intravenous, refeeding with total parenteral nutrition (TPN) solution (32% energy from fat 68% energy from dextrose) (Nelson et al., 2008)