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Anti-obese effect in DIO mice model To evaluate the therapeutic effect of in vivo targeted knock-in of scExe4, we conducted a proof-of-concept study using diet-induced non-genetic obese (DIO) mice, which showed obesity and pre-diabetic symptoms through continuous high fat diet (HFD) feeding (Supplementary Fig

Avoid rapid dose changes during illness or dehydration

Experience chronic fatigue or toxin exposure

Chlamydia, venereal warts (human papilloma virus), or genital herpes are not a cause for deferral if you are feeling healthy and well and meet all other eligibility requirements

Dizziness caused by hypoglycemia may come with other symptoms such as sweating, shaking, confusion, and weakness

On 27 March, NHS England published interim guidance to support commissioners to implement the recommendations in TA1026 during the first 3 years of delivery within the NHS (NHS England, 2025)