Western blotting analysis revealed that the abundance of GLUT4 protein in the mouse uterus on pregnant days 14 was gradually increased, with a peak level on pregnant day 4 (Figure 1B), when the endometrial receptive status begins to be established, the window of implantation. GLUT4 protein expression and distribution were altered within the uterine tissues depending on days of mouse pregnancy, which suggests that GLUT4 expression varies temporally and spatially in response to the changes of ovarian hormones on pregnant days 14
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Another study used a genetic loss of function mouse model to delete the GLP-1R in vagal afferent/effect nerves ( Phox2b-Cre Glp1r flox/flox ) (Sisley et al., 2014)
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This cAMP reduces the indirect activation of the PI3K-Akt signaling pathway and promotes the movement of vesicles containing GLUT4 from the storage pool to the cell membrane (59), thus increasing glucose uptake