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Other causes, such as irritable bowel syndrome (IBS),14 inflammatory bowel disease (IBD), colonic neoplasms, and hyperplastic polyps, could also contribute to the onset of MC.13,15 Some studies show that MC may be connected to the use of non-steroidal anti-inflammatory drugs (NSAIDs),16 vitamin E (VE) deficiency, the intake of unsaturated fatty acids,17 environmental factors,18 family history,3 psoriasis19 and Rett syndrome.20 Feces stasis also plays an important role in the pathogenesis of MC

Overeating can cause uncomfortable fullness or nausea

Patients should be encouraged to report suspected side effects via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)

The researchers searched for the RCTs from a number of databases, including PubMed, EMBASE, Cochrane, and CINAHL

Slowly depress the syringe plunger, allowing the BAC water to run gently down the inside wall of the vial

SIRIC Stratified Oncology Cell DNA Repair and Tumour Immune Elimination (SOCRATE)