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: Analytical identification of GHRH analogs (incl

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

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These GLP-1 analogs affect glucose-dependent insulinotropic polypeptide receptors and glucagon receptors, in addition to GLP-1R and are expected to exhibit stronger anti-obesity effects than that of semaglutide [21, 22]