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"A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity." European Journal of Clinical Pharmacology 80.5 (2024): 669-676

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40 , 41 Molecular Assays

How it works : Metformin works by decreasing hepatic glucose production and increasing insulin sensitivity in muscle cells, which helps lower blood sugar levels

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Each effect maps to a specific physiological pathway that is disrupted by GH decline in the perimenopause transition