Because of the low toxicity of vitamin B 12 , no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board (21)
Adverse reactions following intramuscular (IM) injection have included anxiety, mild transient diarrhea, ataxia, nervousness, pruritus, transitory exanthema, and a feeling of swelling of the entire body
This is one reason the loading schedule is medically supervised rather than something to rush
The way you take your B12 dramatically affects how much actually makes it into your system where it can do its job
(PubMed) Watanabe F, Yabuta Y, Tanioka Y, Bito T
Many research powders are kept refrigerated or frozen until use