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The concentration of serotonin can be modulated by the gut microbiome in multiple ways [230], most notably shown by altered concentration of serotonin and its metabolites in the hippocampus of germ-free animals [231]

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Sasaki M, Shibata E, Tohyama K, Takahashi J, Otsuka K, Tsuchiya K, Takahashi S, Ehara S, Terayama Y, Sakai A (2006) Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinsons disease