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I have had success reducing dosage or frequency, but those individuals are typically on an oral agent as well, such as phentermine, so they have a bridge in the gap left by the GLP-1 reduction." Endocrinology/Diabetes "1

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References: [1] [2] [3] [4] [5] [6] [7] [8]

Insulin sensitivity increased substantially across all dose groups

Phase 1 trial data included groups that started directly at higher doses, and while efficacy was not compromised, GI side effect rates nearly doubled compared to the gradual approach

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