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Histopathologically, medication-induced melanin pigmentation is characterised by the presence of melanin within the lamina propria either as free granules or within melanophages, but without melanocytic hyperplasia
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Injectable administration may cause temporary redness, swelling, or tenderness at the injection site
Y., et al., PLoS Genet
When cells are exposed to ferroptosis inducers, the SQSTM1/p62Keap1Nrf2AKR1C (metal-binding protein MT-1G) pathway is activated, and then activating transcription of quinone oxidoreductase-1, HO-1, and ferritin heavy chain-1, reducing the sensitivity of ferroptosis in the end (Sun et al., 2016b)
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