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Dihexa acts as an analog of angiotensin IV, a compound known to stimulate brain-derived neurotrophic factor (BDNF)
Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (70)
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This can provide a vital basis for clinical decision-making, such as intensifying preoperative nutritional support for high-risk patients, optimizing surgical timing, choosing more refined surgical methods, and conducting closer postoperative monitoring and early intervention (27)
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