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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

Even short-term changes in treatment may have meaningful implications for patients as they navigate the impact of formulary decisions

Gremme, G., Brendel, V., Sparks, M

UK Legal and Regulatory Considerations Under UK law: These peptides are not licensed as medicines and cannot legally be sold, supplied, or marketed for human or veterinary use without MHRA approval

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10.1183/13993003.00419-2019 116 LinssenR